(Pyr3)-Amyloid β-Protein (3-42) ammonium salt

Names

[ Name ]:
(Pyr3)-Amyloid β-Protein (3-42) ammonium salt

[Synonym ]:
pyr-phe-arg-his-asp-ser-gly-tyr-glu-val-his-his-gln-lys-leu-val-phe-phe-ala-glu-asp-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val-ile-ala trifluoroacetate
MFCD03457978
Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Biological Activity

[Description]:

(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Takahashi-Ito K, et.al. Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates. Biochem Biophys Res Commun. 2017 Nov 4;493(1):158-163.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉₆H₂₉₉N₅₃O₅₅S

[ Molecular Weight ]:
4309.86

[ Exact Mass ]:
4307.19000

[ PSA ]:
1722.65000

[ LogP ]:
5.49010

[ Appearance of Characters ]:
solid

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds

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