Exatecan Intermediate 2

Names

[ Name ]:
Exatecan Intermediate 2

[Synonym ]:
2-acetylamino-8-amino-6-fluoro-5-methyl-l-tetralone
2-Acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone

Biological Activity

[Description]:

Exatecan Intermediate 2 (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[References]

[1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.

[2]. Lv Xianyu, et al. Preparation of camptothecin derivative intermediate. China, CN115197088. 2022-10-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₅FN₂O₂

[ Molecular Weight ]:
250.27

[ Exact Mass ]:
250.11200

[ PSA ]:
75.68000

[ LogP ]:
2.77140

Related Compounds

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