NTRC 00660

A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM; displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4; shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM); increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel.

References 1. Maia AR, et al. Ann Oncol. 2015 Oct;26(10):2180-92. 2. Libouban MAA, et al. Oncotarget. 2017 Jun 13;8(24):38309-38325. 3. Zaman GJR, et al. Mol Cancer Ther. 2017 Jul 27. pii: molcanther.0342.2017. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK)