Tos-O-C4-NH-Boc

Names

[ Name ]:
Tos-O-C4-NH-Boc

[Synonym ]:
Toluene-4-sulfonic acid 4-tert-butoxy-carbonylamino-butyl ester

Biological Activity

[Description]:

Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₅NO₅S

[ Molecular Weight ]:
343.43800

[ Exact Mass ]:
343.14500

[ PSA ]:
93.57000

[ LogP ]:
4.29040

Related Compounds

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