EPZ-030456

Names

[ Name ]:
EPZ-030456

Biological Activity

[Description]:

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM; displays noncompetitive inhibition with respect to SAM and MEKK2 with Ki of 1.2 and 1.1 nM, respectively; has cellular potency (IC50=48 nM) suitable to probe the in vitro biology of SMYD3 inhibition.

[References]

References 1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8. View Related Products by Target Histone Methyltransferase (HMTase)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₄ClN₅O₄S

[ Molecular Weight ]:
572.121

Related Compounds

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