endo-BCN-PEG4-NHS ester

Names

[ Name ]:
endo-BCN-PEG4-NHS ester

[Synonym ]:
MFCD23704191
(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl {15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}carbamate
Carbamic acid, N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester

Biological Activity

[Description]:

endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₆H₃₈N₂O₁₀

[ Molecular Weight ]:
538.587

[ Exact Mass ]:
538.252625

[ LogP ]:
-0.81

[ Index of Refraction ]:
1.544

Related Compounds

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