Mc-VC-PAB-SN38

Names

[ Name ]:
Mc-VC-PAB-SN38

Biological Activity

[Description]:

Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Camptothecins

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₁H₅₈N₈O₁₃

[ Molecular Weight ]:
991.05

Mc-VC-PAB-SN38

Names

Biological Activity

Chemical & Physical Properties

Related Compounds