Eniporide

Names

[ Name ]:
Eniporide

[Synonym ]:
UNII-7IGF9182QU
Eniporide
N-(diaminomethylidene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide
N-Carbamimidoyl-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide
Benzamide, N-(aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)-
EMD96785

Biological Activity

[Description]:

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

ENIPORIDE 是一种有效的 Na+/H+ 交换抑制剂。

[In Vivo]

Eniporide (3mg /kg；静脉注射；心脏骤停前全身输注) 可改善晶体性心脏骤停引起的缺血/再灌注健康猪心脏的功能和高能量磷酸盐含量[1]。 Animal Model: Clinically relevant pig models of cardiopulmonary bypass (CPB) and cardioplegia[1] Dosage: 3 mg/kg Administration: IV; systemic infusion before cardioplegia with added 2 μM Eniporide or not Result: Had no effect on standard hemodynamics including vascular pressures and cardiac index nor for cardiac performance factors. Reduced myocardial edema and improves heart function.

[References]

[1]. Zeymer U, et al. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38(6):1644-50.

[2]. Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77(2):658-63.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
635.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₆N₄O₃S

[ Molecular Weight ]:
320.37

[ Flash Point ]:
338.4±34.3 °C

[ Exact Mass ]:
320.094299

[ PSA ]:
128.92000

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.656

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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