4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
Names
[ CAS No. ]:
174264-46-1
[ Name ]:
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
[Synonym ]:
6-Hydroxy-4 inverted exclamation mark-tert-butyldimethylsylyl Raloxifene
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
Biological Activity
[Description]:
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide[1].
[Related Catalog]:
[In Vitro]
The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide[1].
[References]
Chemical & Physical Properties
[ Density]:
1.15g/cm3
[ Boiling Point ]:
706.195ºC at 760 mmHg
[ Molecular Formula ]:
C34H41NO4SSi
[ Molecular Weight ]:
587.84400
[ Flash Point ]:
380.893ºC
[ Exact Mass ]:
587.25300
[ PSA ]:
87.24000
[ LogP ]:
8.69150
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.593