Efaproxiral sodium

Names

[ Name ]:
Efaproxiral sodium

[Synonym ]:
Efaproxiral sodium
Revaproxyn
RSR-13
Sodium 2-(4-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}phenoxy)-2-methylpropanoate
RSR 13 sodium
Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-, sodium salt (1:1)
Efaproxiral (sodium)

Biological Activity

[Description]:

Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

[References]

[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
554.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₂NNaO₄

[ Molecular Weight ]:
363.383

[ Flash Point ]:
289.2ºC

[ Exact Mass ]:
363.144653

[ PSA ]:
78.46000

[ LogP ]:
2.46490

[ Vapour Pressure ]:
3.93E-13mmHg at 25°C

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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