α-Conotoxin EI

Names

[ Name ]:
α-Conotoxin EI

[Synonym ]:
ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS-NH2
A-CONOTOXIN EL
ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS
RDHYPCCYHPTCNMSNPQIC-NH2
H-ARG-ASP-HYP-CYS-CYS-TYR-HIS-PRO-THR-CYS-ASN-MET-SER-ASN-PRO-GLN-ILE-CYS-NH2
a-Conotoxin El,Conus ermineus

Biological Activity

[Description]:

α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[Target]

IC50: 187 nM (nicotinic acetylcholine α1β1γδ receptor)[3]

[In Vitro]

α-Conotoxin EI (10 µM) blocks muscle and ganglionic receptors, but less potent for the central nevous system receptor[3]. α-Conotoxin EI (10 µM) blocks the α1β1γδ receptors with a τon of 4.9 s, and blocks the α3β4 receptor with a τon of 11 s[3].

[In Vivo]

α-Conotoxin EI (intraperitoneal injection) into mice induces muscular weakness, followed by flaccid paralysis and ultimately death[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₃H₁₂₅N₂₇O₂₇S₅

[ Molecular Weight ]:
2093.37000

[ Exact Mass ]:
2091.78000

[ PSA ]:
1002.01000

Related Compounds

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