CGS 27023A

Names

[ Name ]:
CGS 27023A

[Synonym ]:
N-Hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(3-pyridinylmethyl)-D-valinamide hydrochloride (1:1)
Butanamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](3-pyridinylmethyl)amino]-3-methyl-, (2R)-, hydrochloride (1:1)

Biological Activity

[Description]:

CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9.

[In Vitro]

CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9; shows growth-inhibitory effects in breast carcinoma, prostate, bladder, colon, lung adenocarcinoma, glioblastoma, and ovarian carcinoma cell line;.protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits.Solid TumorsPhase 2 Discontinued

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₄ClN₃O₅S

[ Molecular Weight ]:
429.918

[ Exact Mass ]:
429.112518

Related Compounds

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