Eleutheroside B1

Names

[ Name ]:
Eleutheroside B1

Biological Activity

[Description]:

Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[In Vitro]

Eeutheroside B1 (100 µg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells[1]. RT-PCR[1] Cell Line: Virus-infected A549 cells Concentration: 100 µg/ml Incubation Time: 24 hours Result: The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased.

[References]

[1]. Yan W, et al. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med. 2018 Nov;42(5):2776-2792.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₀O₁₀

[ Molecular Weight ]:
384.33500

[ Exact Mass ]:
384.10600

[ PSA ]:
148.05000

Related Compounds

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