Gallopamil hydrochloride

Names

[ Name ]:
Gallopamil hydrochloride

[Synonym ]:
D600
GALLOPAMIL
GALLOPAMIL HYDROCHLORIDE
D600,HCL
(S)-Gallopamil
(+/-)-METHOXYVERAPAMIL HCL
(+/-)-METHOXYVERAPAMIL,HYDROCHLORIDE
GALLOPAMIL HCL
D 600 HYDROCHLORIDE

Biological Activity

[Description]:

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

[Target]

Ca2+

[In Vivo]

Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3]. Animal Model: Male Wistar rats weighing 290-370 g[3] Dosage: 0.2 mg/kg Administration: i.v.; 5 min Result: Markedly reduced VT and totally prevented VF.

[References]

[1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115.

[2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14.

[3]. Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21.

Chemical & Physical Properties

[ Density]:
1.068g/cm3

[ Boiling Point ]:
605.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₄₁ClN₂O₅

[ Molecular Weight ]:
521.08900

[ Flash Point ]:
320.2ºC

[ Exact Mass ]:
520.27000

[ PSA ]:
73.18000

[ LogP ]:
5.90368

[ Storage condition ]:
-20°C

Safety Information

[ WGK Germany ]:
3

Related Compounds

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