JG-231
Names
[ CAS No. ]:
1627126-59-3
[ Name ]:
JG-231
Biological Activity
[Description]:
JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip).
[References]
References 1. Shao H, et al. J Med Chem. 2018 Jul 13. doi: 10.1021/acs.jmedchem.8b00583. View Related Products by Target Heat Shock Protein (HSP)
Chemical & Physical Properties
[ Molecular Formula ]:
C22H18BrCl2N3OS4
[ Molecular Weight ]:
619.45