HQL 79

Names

[ Name ]:
HQL 79

[Synonym ]:
4-(Diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]piperidine
HQL
Piperidine, 4-(diphenylmethoxy)-1-[3-(1H-tetrazol-5-yl)propyl]-
cc-704
2cvd
HQL-79
4-Benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]-piperidine

Biological Activity

[Description]:

HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> PGE synthase

[Target]

IC50: 6 μM (H-PGDS)[1] Kd: 0.8 μM (H-PGDS)[1]

[In Vitro]

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].

[References]

[1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
553.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₇N₅O

[ Molecular Weight ]:
377.48

[ Flash Point ]:
288.6±32.9 °C

[ Exact Mass ]:
377.221558

[ PSA ]:
66.93000

[ LogP ]:
3.94

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.619

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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