Lp-PLA2-IN-11

Names

[ CAS No. ]:
1620680-19-4

[ Name ]:
Lp-PLA2-IN-11

Biological Activity

[Description]:

Lp-PLA2-IN-11 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-11 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2014114249A1, compound E145)[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

Lp-PLA2[1]

[References]

[1]. Zehong Wan, et al. Bicyclic pyrimidone compounds as inhibitors of lp-pla2. Patent WO2014114249A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀F₄N₄O₃

[ Molecular Weight ]:
464.41

Related Compounds

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