2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D

Names

[ CAS No. ]:
162049-83-4

[ Name ]:
2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D

[Synonym ]:
(2-[2-(3-Trifluoromethyl)phenyl)-1H-imidazol-4-yl]ethanamine dimaleate Compound 39
2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₀F₃N₃O₈

[ Molecular Weight ]:
487.38300

[ Exact Mass ]:
487.12000

[ PSA ]:
203.90000

[ LogP ]:
2.72060

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 2811 6.1/PG 3

Articles

Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.

J. Med. Chem. 38 , 1287-1294, (1995)

New histamine derivatives characterized by a (substituted) aryl, heteroaryl, benzyl, or heteroarylmethyl substituent in the C2 position of the imidazole ring have been prepared from appropriate imidat...

Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion.

Invest. Ophthalmol. Vis. Sci. 53(6) , 2993-3003, (2012)

The purpose of this study was to determine the effect of histamine and its receptors on goblet cell secretion.Cultured rat and human goblet cells were grown in RPMI 1640. Goblet cell secretion of high...

Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor.

J. Pharmacol. Exp. Ther. 305 , 1104-1115, (2003)

Species isoforms of histamine H2-, H3-, and H4-receptors differ in their pharmacological properties. The study aim was to dissect differences between the human H1R (hH1R) and guinea pig H1R (ghH1R). W...