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DMP 543

Names

[ CAS No. ]:
160588-45-4

[ Name ]:
DMP 543

[Synonym ]:
HMS3268N10
TCN 237 dihydrochloride
DMP 543

Biological Activity

[Description]:

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

KV7 channel


[In Vitro]

DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].

[References]

[1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409.

[2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Chemical & Physical Properties

[ Density]:
1.319g/cm3

[ Boiling Point ]:
593.1ºC at 760mmHg

[ Molecular Formula ]:
C26H18F2N2O

[ Molecular Weight ]:
412.43

[ Flash Point ]:
312.5ºC

[ Exact Mass ]:
412.13900

[ PSA ]:
42.85000

[ LogP ]:
5.07070

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.643

Related Compounds