(S)-16-Amino-10-benzyl-6,9,12,15-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecanoic acid

Names

[ Name ]:
(S)-16-Amino-10-benzyl-6,9,12,15-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecanoic acid

Biological Activity

[Description]:

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[References]

[1]. Masuda,et al. Preparation of antibody-drug conjugates for cancer therapy. World Intellectual Property Organization, WO2014057687 A1. 2014-04-17.

Chemical & Physical Properties

[ Density]:
1.339±0.06 g/cm3(Predicted)

[ Boiling Point ]:
971.9±65.0 °C(Predicted)

[ Molecular Formula ]:
C₁₈H₂₅N₅O₇

[ Molecular Weight ]:
423.42