Wikstrol A

Names

[ Name ]:
Wikstrol A

[Synonym ]:
[3,8'-Bi-4H-1-benzopyran]-4-one, 2',3'-dihydro-3',5,5',7,7'-pentahydroxy-2,2'-bis(4-hydroxyphenyl)-
3',5,5',7,7'-Pentahydroxy-2,2'-bis(4-hydroxyphenyl)-3',4'-dihydro-2'H,4H-3,8'-bichromen-4-one

Biological Activity

[Description]:

Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC50 value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC50 value of 67.8 µM[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

HIV-1:67.8 (IC50)

[References]

[1]. Hu K, et al. Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica. Planta Med. 2000 Aug;66(6):564-7.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
925.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₂₂O₁₀

[ Molecular Weight ]:
542.490

[ Flash Point ]:
311.8±27.8 °C

[ Exact Mass ]:
542.121277

[ LogP ]:
4.63

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.786

Related Compounds

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