L-NIO dihydrochloride

Names

[ Name ]:
L-NIO dihydrochloride

[Synonym ]:
(E)-N-(1-Aminoethylidene)-L-ornithine dihydrochloride
L-Ornithine, N-(1-aminoethylidene)-, (E)-, hydrochloride (1:2)

Biological Activity

[Description]:

L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[Target]

Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]

[References]

[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9.

[2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₇Cl₂N₃O₂

[ Molecular Weight ]:
246.135

[ Exact Mass ]:
245.069778

[ Appearance of Characters ]:
NA

[ Storage condition ]:
2-8℃

L-NIO dihydrochloride

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds