BTS

Names

[ Name ]:
BTS

[Synonym ]:
p-Toluenesulfonamide,N-benzyl
N-Tosylbenzylamine
N-Benzyl-4-methylbenzenesulfonamide
N-Benzyl-p-toluenesulfonamide
N-Benzyl-p-toluenesulphonamide
N-Benzyl-4-methyl-benzenesulfonamide
MFCD00159328
BTS

Biological Activity

[Description]:

BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. IC50 value: 5 uMTarget: Ca2+-stimulated myosin S1 ATPaseBTS also weakens myosin’s interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Myosin

Research Areas >> Cancer

[References]

[1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.204 g/cm3

[ Boiling Point ]:
419.1ºC at 760 mmHg

[ Melting Point ]:
115 °C

[ Molecular Formula ]:
C₁₄H₁₅NO₂S

[ Molecular Weight ]:
261.33900

[ Flash Point ]:
207.3ºC

[ Exact Mass ]:
261.08200

[ PSA ]:
54.55000

[ LogP ]:
3.94520

[ Vapour Pressure ]:
3.12E-07mmHg at 25°C

[ Index of Refraction ]:
1.589

[ Storage condition ]:
Desiccate at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT5490000

CHEMICAL NAME :: p-Toluenesulfonamide, N-benzyl-

CAS REGISTRY NUMBER :: 1576-37-0

BEILSTEIN REFERENCE NO. :: 2217277

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H15-N-O2-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,41,1953

Safety Information

[ RTECS ]:
XT5490000

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

BTS