PEG5-Tos

Names

[ Name ]:
PEG5-Tos

[Synonym ]:
3,6,9,12-Tetraoxatetradecane-1,14-diol, mono(4-methylbenzenesulfonate)
14-Hydroxy-3,6,9,12-tetraoxatetradec-1-yl 4-methylbenzenesulfonate

Biological Activity

[Description]:

PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
524.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₈O₈S

[ Molecular Weight ]:
392.464

[ Flash Point ]:
270.9±30.1 °C

[ Exact Mass ]:
392.150482

[ LogP ]:
-0.48

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.506

Related Compounds

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