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NCT-502

Names

[ CAS No. ]:
1542213-00-2

[ Name ]:
NCT-502

Biological Activity

[Description]:

NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 3.7 μM (PHGDH)[1]


[In Vitro]

NCT-502 is cytotoxic to MDA-MB-468, with an EC50 of 15.2 µM[1].

[References]

[1]. Rohde JM, et al. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018 May 1;26(8):1727-1739.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H20F3N5S

[ Molecular Weight ]:
395.45

[ Storage condition ]:
2-8℃

Related Compounds