Adenosine 2',5'-diphosphate sodium

Names

[ Name ]:
Adenosine 2',5'-diphosphate sodium

Biological Activity

[Description]:

Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist. Adenosine 2',5'-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

[Target]

Human Endogenous Metabolite

[In Vitro]

Adenosine 2',5'-diphosphate non-selectively antagonizes the platelet P2X1 ion channel[1].

[References]

[1]. Boyer JL, et al. Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol. 1996;50(5):1323-1329.

[2]. Toth-Zsamboki E, et al. The P2Y1 receptor antagonist adenosine-2',5'-diphosphate non-selectively antagonizes the platelet P2X1 ion channel. Thromb Haemost. 2001;86(5):1338-1339.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₅N₅O₁₀P_2.xNa

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Identification of competitive antagonists of the P2Y1 receptor.

Mol. Pharmacol. 50 , 1323-1329, (1996)

Although P2 receptors mediate a myriad of physiological effects of extracellular adenine nucleotides, study of this broad class of receptors has been compromised by a lack of P2 receptor-selective ant...

P2y1 and P2y2 receptor-operated Ca2+ signals in primary cultures of cardiac microvascular endothelial cells.

Microvasc. Res. 61 , 240-252, (2001)

Intracellular Ca2+ signals elicited by nucleotide agonists were investigated in primary cultures of rat cardiac microvascular endothelial cells using the fura-2 technique. UTP increased the intracellu...

Characterisation of pea cytosolic glutathione reductase expressed in transgenic tobacco.

Planta 211 , 537-545, (2000)

Expression in transgenic tobacco (Nicotiana tabacum L.) of a pea (Pisum sativum L.) GOR2 cDNA, encoding an isoform of glutathione reductase (GOR2), resulted in a 3- to 7-fold elevation of total foliar...

Related Compounds

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