THREO-DIHYDROBUPROPION

Names

[ Name ]:
THREO-DIHYDROBUPROPION

[Synonym ]:
(R*,R*)-2-(T-BUTYLAMINO)1-(3-CHLOROPHENYL) PROPANOL MALEATE
(R*,R*)-2-(T-BUTYLAMINO)1-(3-CHLOROPHENYL) PROPANOL
threo-Hydroxy Bupropion HCl
THREO-HYDROBUPROPION

Biological Activity

[Description]:

Threo-dihydrobupropion is a major metabolite of Bupropion, formed via oxidation and reduction exhibit pharmacological activity. Bupropion, a dual dopamine-norepinephrine uptake inhibitor and a nicotine receptor antagonist, is widely used in the management of depression and as a smoking cessation aid[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Andrea R Masters, et al. Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:201-208.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₀ClNO

[ Molecular Weight ]:
241.75700

[ Exact Mass ]:
241.12300

[ PSA ]:
32.26000

[ LogP ]:
3.54090

Related Compounds

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