Lurtotecan

Names

[ Name ]:
Lurtotecan

[Synonym ]:
GG 211
11H-1,4-Dioxino(2,3-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-((4-methyl-1-piperazinyl)methyl)-,(8S)
NX 211
(7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin)
OSI-211
7-[(4-methylpiperazino)methyl]-10,11-(ethylenedioxy)-(20S)-camptothecin

Biological Activity

[Description]:

Lurtotecan (GI147211; OSI-211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase I

[References]

[1]. D L Emerson, et al. In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues. Cancer Res. 1995 Feb 1;55(3):603-9.

Chemical & Physical Properties

[ Density]:
1.5g/cm3

[ Boiling Point ]:
844.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₃₀N₄O₆

[ Molecular Weight ]:
518.56100

[ Flash Point ]:
464.7ºC

[ Exact Mass ]:
518.21700

[ PSA ]:
106.36000

[ LogP ]:
1.47400

[ Vapour Pressure ]:
2.51E-30mmHg at 25°C

[ Index of Refraction ]:
1.73

[ Storage condition ]:
-20°C

Related Compounds

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