FM1-43

Names

[ Name ]:
FM1-43

[Synonym ]:
Neurodye GH1-43
3-[4-[(E)-2-[4-(dibutylamino)phenyl]ethenyl]pyridin-1-ium-1-yl]propyl-triethylazanium,dibromide
SynaptoGreen™ C4
N-(3-Triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide
N-(3-TRIETHYLAMMONIUMPROPYL)-4-(4-(DIBUTYLAMINO)STYRYL)PYRIDINIUM DIBROMIDE

Biological Activity

[Description]:

FM1-43, a styryl dye used to study endocytosis and exocytosis, behaves as a permeant blocker of the hair-cell mechanotransducer channel. FM1-43 also reduces the ototoxic effects of the aminoglycoside antibiotic neomycin sulfate[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. J E Gale, et al. FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. J Neurosci. 2001 Sep 15;21(18):7013-25.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₉Br₂N₃

[ Molecular Weight ]:
611.53800

[ Exact Mass ]:
609.22900

[ PSA ]:
7.12000

[ LogP ]:
0.82570

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Regulation of density of functional presynaptic terminals by local energy supply.

Mol. Brain 8 , 42, (2015)

The density of functional synapses is an important parameter in determining the efficacy of synaptic transmission. However, how functional presynaptic terminal density is regulated under natural physi...

A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.

Dev. Neurobiol. 75 , 961-83, (2015)

MYO7A is an unconventional myosin involved in the structural organization of hair bundles at the apex of sensory hair cells (SHCs) where it serves mechanotransduction in the process of hearing and bal...

A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.

Neuropharmacology 92 , 146-57, (2015)

Alzheimer's disease is a neurodegenerative disorder characterized by deposition of β-amyloid (Aβ) fibrils accompanied with progressive neurite loss. None of the clinically approved anti-Alzheimer's ag...