FTase Inhibitor I
Names
[ CAS No. ]:
149759-96-6
[ Name ]:
FTase Inhibitor I
[Synonym ]:
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylbutyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
B581
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.161g/cm3
[ Boiling Point ]:
716.1ºC at 760mmHg
[ Molecular Formula ]:
C22H38N4O3S2
[ Molecular Weight ]:
470.69
[ Flash Point ]:
386.9ºC
[ Exact Mass ]:
470.23900
[ PSA ]:
180.58000
[ LogP ]:
3.25410
[ Appearance of Characters ]:
solid | white
[ Vapour Pressure ]:
1.6E-21mmHg at 25°C
[ Index of Refraction ]:
1.566
[ Storage condition ]:
−20°C
[ Water Solubility ]:
H2O: soluble
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
Gan To Kagaku Ryoho. 24(2) , 145-55, (1997)
Posttranslational farnesylation by farnesyltransferase (FTase) is critical for the function of ras oncogene product and FTase has attracted attention as the new target of anticancer agents. B956 and B...
Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.Oncogene 18(35) , 4930-9, (1999)
IL-2 deprivation triggers apoptosis in the murine T cell line TS1alphabeta, a process that can be blocked by overexpression of Bcl-2. Here we show that Bcl-2 and Ras proteins interact in mitochondria ...
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.J. Biol. Chem. 268(25) , 18415-8, (1993)
The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, t...