Amyloid β-Protein (31-35)

Names

[ Name ]:
Amyloid β-Protein (31-35)

[Synonym ]:
IIGLM
Isoleucinyl-isoleucinyl-glycinyl-leucinyl-methionine
amyloid B-protein fragment 31-35*acetate
ILE-ILE-GLY-LEU-MET
Amyloid β-Protein (31-35)
β-Amyloid (31-35)

Biological Activity

[Description]:

β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Amyloid-β

Peptides

Research Areas >> Neurological Disease

[In Vitro]

β-Amyloid (31-35) is a functional cytotoxic domain of Aβ peptide. β-Amyloid (31-35) increases the phosphorylation of biotinylated Aβ(1-40), enhances CDK-1 activity, and also inhibits binding of Aβ to cyclin B1. β-Amyloid (31-35) is cytotoxic, and such an effect can be inhibited by olomoucine in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 (NT-2) neurons[1]. β-Amyloid (31-35) shows cytotoxic effect on cerebellar granule cells (CGC). β-Amyloid (31-35) also increases caspase-3 activity in a time-dependent manner (4-24 h) at 40 μM[2].

[References]

[1]. Milton NG, et al. The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. Neurosci Lett. 2002 Apr 5;322(2):131-3.

[2]. Misiti F, et al. Fragment 31-35 of beta-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation. A crucial role for the redox state of methionine-35 residue. Neurochem Int. 2006 Oct;49(5):525-32.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.137 g/cm3

[ Boiling Point ]:
866.382ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₄₇N₅O₆S

[ Molecular Weight ]:
545.73600

[ Exact Mass ]:
545.32500

[ PSA ]:
205.02000

[ LogP ]:
3.12420

[ Storage condition ]:
−20°C

Amyloid β-Protein (31-35)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds