H-ILE-ARG-VAL-VAL-MET-OH

Names

[ Name ]:
H-ILE-ARG-VAL-VAL-MET-OH

[Synonym ]:
ile-arg-val-val-met

Biological Activity

[Description]:

H-ILE-ARG-VAL-VAL-MET-OH is a pentapeptide from C7 with a domain that supports cell attachment. H-ILE-ARG-VAL-VAL-MET-OH is also the sequence fragment that binds to the thrombospondin-1 (TS1) receptor[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Thrombospondin-1 (TS1) receptor[2]

[In Vitro]

H-ILE-ARG-VAL-VAL-MET-OH 支持 G361 黑色素瘤、K562 红白血病细胞、HT1080 纤维肉瘤、C32 无色素黑色素瘤和内皮细胞的附着。H-ILE-ARG-VAL-VAL-MET-OH 还抑制细胞与 TS1 的重组细胞结合域 (CBD) 的粘附[1]。

[References]

[1]. Kosfeld MD, et al. Identification of a new cell adhesion motif in two homologous peptides from the COOH-terminal cell binding domain of human thrombospondin. J Biol Chem. 1993 Apr 25;268(12):8808-14.

[2]. Frazier, et al. Thrombospondin 1 subfragments that bind to thrombospondin 1 receptor and inhibit cell adhesion: United States, US5399667[P]. 1995-03-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₅₂N₈O₆S

[ Molecular Weight ]:
616.81700

[ Exact Mass ]:
616.37300

[ PSA ]:
266.92000

[ LogP ]:
3.16680

Related Compounds

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