Ac-Leu-Val-Lys-aldehyde

Names

[ Name ]:
Ac-Leu-Val-Lys-aldehyde

[Synonym ]:
cathepsin b inhibitor ii
N-Acetyl-L-leucyl-N-[(2S)-6-amino-1-oxo-2-hexanyl]-L-valinamide
L-Valinamide, N-acetyl-L-leucyl-N-[(1S)-5-amino-1-formylpentyl]-
ac-lvk-cho
acetyl-L-leucyl-L-valyl-L-lysinal
ac-leu-val-l-lysinal

Biological Activity

[Description]:

Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

Cathepsin B:4 nM (IC50)

[References]

[1]. McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9.

[2]. Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
665.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₆N₄O₄

[ Molecular Weight ]:
384.51

[ Flash Point ]:
356.3±31.5 °C

[ Exact Mass ]:
384.273651

[ PSA ]:
130.39000

[ LogP ]:
0.88

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.488

Related Compounds

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