Cyclo(Phe-Pro)

Names

[ Name ]:
Cyclo(Phe-Pro)

[Synonym ]:
3-Benzyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
3-Benzylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(phenylmethyl)-
cyclo(phenylalanyl-prolyl)

Biological Activity

[Description]:

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
509.5±39.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₆N₂O₂

[ Molecular Weight ]:
244.289

[ Flash Point ]:
262.0±27.1 °C

[ Exact Mass ]:
244.121185

[ LogP ]:
-0.56

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.614

Related Compounds

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