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JTV-519 free base

Names

[ CAS No. ]:
145903-06-6

[ Name ]:
JTV-519 free base

[Synonym ]:
K201 free base
JTV-519 hemifumarate
4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
K201
UNII-EBY0ENK2GQ
K21
JTV 519

Biological Activity

[Description]:

JTV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Cardioprotective agent[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cardiovascular Disease

[References]

[1]. Darcy YL, et al. K201 (JTV519) is a Ca2+-Dependent Blocker of SERCA and a Partial Agonist of Ryanodine Receptors in Striated Muscle. Mol Pharmacol. 2016 Aug;90(2):106-15.

Chemical & Physical Properties

[ Density]:
1.153 g/cm3

[ Boiling Point ]:
615.133ºC at 760 mmHg

[ Molecular Formula ]:
C25H32N2O2S

[ Molecular Weight ]:
424.59900

[ Flash Point ]:
325.821ºC

[ Exact Mass ]:
424.21800

[ PSA ]:
58.08000

[ LogP ]:
4.35010

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H413

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds