RUSKI-201

Names

[ Name ]:
RUSKI-201

[Synonym ]:
Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-
2-[(2-Methylbutyl)amino]-1-[4-(6-methyl-2-pyridinyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]ethanone

Biological Activity

[Description]:

A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.

[References]

References 1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. View Related Products by Target Hedgehog (Hh)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
520.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₇N₃OS

[ Molecular Weight ]:
357.513

[ Flash Point ]:
268.7±30.1 °C

[ Exact Mass ]:
357.187469

[ LogP ]:
3.26

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.576

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.