HUHS015

Names

[ Name ]:
HUHS015

[Synonym ]:
1H-Pyrazol-5-ol, 3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-
4-Benzyl-3-méthyl-1-(6-méthyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol
4-Benzyl-3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol
4-Benzyl-3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol
4-Benzyl-3-méthyl-1-(5-méthyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol
1H-Pyrazol-5-ol, 3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-
HUHS015

Biological Activity

[Description]:

HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. [1]

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

[References]

[1]. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
585.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₈N₄O

[ Molecular Weight ]:
318.372

[ Flash Point ]:
307.7±27.9 °C

[ Exact Mass ]:
318.148071

[ LogP ]:
4.72

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.689

[ Storage condition ]:
2-8℃

Related Compounds

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