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FPI-1523

Names

[ CAS No. ]:
1452459-50-5

[ Name ]:
FPI-1523

Biological Activity

[Description]:

FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

β-lactamase[1]


[In Vitro]

FPI-1523 inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1]. FPI-1523 inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1].

[References]

[1]. King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H14N4O7S

[ Molecular Weight ]:
322.30

Related Compounds