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Endothelin-1 (11-21) trifluoroacetate salt

Names

[ CAS No. ]:
144602-02-8

[ Name ]:
Endothelin-1 (11-21) trifluoroacetate salt

[Synonym ]:
cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp

Biological Activity

[Description]:

IRL 1038 is an endothelin B receptor selective antagonist with a Ki of 6-11 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 6-11 nM (endothelin B receptors), 0.4-0.7 μM (endothelin A receptors)[1]


[References]

[1]. Urade Y, et al. An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]-endothelin-1(11-21). FEBS Lett. 1992 Oct 12;311(1):12-6. doi: 10.1016/0014-5793(92)81355-p.  

Chemical & Physical Properties

[ Density]:
1.282g/cm3

[ Boiling Point ]:
1720.5ºC at 760 mmHg

[ Molecular Formula ]:
C68H92N14O15S2

[ Molecular Weight ]:
1409.67000

[ Flash Point ]:
994.3ºC

[ Exact Mass ]:
1408.63000

[ PSA ]:
506.92000

[ LogP ]:
6.15200

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.59

Related Compounds