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Dofetilide N-oxide

Names

[ CAS No. ]:
144449-71-8

[ Name ]:
Dofetilide N-oxide

[Synonym ]:
N-[4-(2-{[2-(4-methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide N-oxide

Biological Activity

[Description]:

Dofetilide N-oxide (UK-116856) is a metabolite of Dofetilide. Dofetilide is a class III antiarrhythmic agent that blocks potassium channels[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

Potassium channels[1][2]


[References]

[1]. Maisch B, et al. Pregnancy and cardiomyopathies. Herz. 2003 May;28(3):196-208.

[2]. Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H27N3O6S2

[ Molecular Weight ]:
457.56400

[ Exact Mass ]:
457.13400

[ PSA ]:
147.76000

[ LogP ]:
4.32400

Related Compounds