Neuropeptide Y (3-36) (porcine) trifluoroacetate salt

Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36[1][2][3].

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

NPY Y2 receptor

Neuropeptide Y (3-36) (porcine) accounts for 35% of NPY-like immunoreactivity in porcine brain[2].   Neuropeptide Y (3-36) (porcine) shows high affinity for Y2-like receptors on CHP234 cells, and light affinity Y1-like receptors on SK-N-MC cells[2].

Neuropeptide Y (3-36) (porcine) (0.24-24 nM; i.c.v.; single dose) induces feeding in the rat in a dose-dependent manner[1]. Neuropeptide Y (3-36) (porcine) (4 μg, 8 μg; i.c.v.; single dose) significantly increased food intake at 2 and 3 h, results dose-dependently orexigenic effect in rainbow trout (Oncorhynchus mykiss)[2]. Animal Model: Adult male Wistar rats (250-300 g)[1] Dosage: 0.24, 0.72, 2.4, 7.2, 24 nM per animal Administration: Intracerebroventricular injection; single dose Result: Stimulated rat feeding dose-dependently. Produced no feeding effect alone, that Y2 activation alone elicited no feeding response.