L 012 sodium salt

Names

[ Name ]:
L 012 sodium salt

[Synonym ]:
MFCD30378369
MFCD27991293
Pyrido[3,4-d]pyridazin-1(2H)-one, 8-amino-5-chloro-4-hydroxy-7-phenyl-, sodium salt (1:1)
Sodium 8-amino-5-chloro-1-oxo-7-phenyl-1,2-dihydropyrido[3,4-d]pyridazin-4-olate

Biological Activity

[Description]:

L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2•−) and identify Nox inhibitors[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

L-012 sodium salt, a chemical analog of luminol, gives rise to significantly higher luminescence yield and increased sensitivity as compared to other CL probes, lucigenin and MCLA[1].

[In Vivo]

L-012 sodium salt is well distributed in the mouse body and mediates a strong ROS/RNS-dependent luminescent signal in vivo and is useful for monitoring the development and regulation of inflammation in living organisms[2].

[References]

[1]. Zielonka J, et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med. 2013;65:1310-1314.

[2]. Kielland A, et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med. 2009;47(6):760-766.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₈ClN₄NaO₂

[ Molecular Weight ]:
310.671

[ Exact Mass ]:
310.023346

Related Compounds

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