Tin-protoporphyrin IX

Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].

Research Areas >> Cancer

IC50: Heme oxygenase-1 (HO-1)[1]

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1]. Cell Viability Assay[1] Cell Line: Capan-1, CD18/HPAF, PDAC cells Concentration: 20 μM, 50 μM Incubation Time: 24 or 72 hours Result: Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1]. Animal Model: Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20 Result: Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).

[1]. Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.