Luvadaxistat

Names

[ Name ]:
Luvadaxistat

[Synonym ]:
4-Hydroxy-6-{2-[4-(trifluoromethyl)phenyl]ethyl}-3(2H)-pyridazinone
3(2H)-Pyridazinone, 4-hydroxy-6-[2-[4-(trifluoromethyl)phenyl]ethyl]-

Biological Activity

[Description]:

TAK-831 is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO) and can be used in studies of schizophrenia[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Wang H, Norton J, Xu L, DeMartinis N, Sen R, Shah A, Farmer J, Lynch D. Results of a randomized double-blind study evaluating luvadaxistat in adults with Friedreich ataxia. Ann Clin Transl Neurol. 2021 Jun;8(6):1343-1352.

[2]. Yoneyama T, Sato S, Sykes A, Fradley R, Stafford S, Bechar S, Howley E, Patel T, Tagawa Y, Moriwaki T, Asahi S. Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice. Pharm Res. 2020 Aug 5;37(8):164.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₃H₁₁F₃N₂O₂

[ Molecular Weight ]:
284.23

[ Exact Mass ]:
284.077271

[ LogP ]:
1.76

[ Index of Refraction ]:
1.557

Related Compounds

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