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Mutant EGFR inhibitor

Names

[ CAS No. ]:
1421373-62-7

[ Name ]:
Mutant EGFR inhibitor

[Synonym ]:
N-[5-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide
Mutant EGFR inhibitor

Biological Activity

[Description]:

Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.

[Related Catalog]:

Research Areas >> Cancer

[Target]

EGFRL858R

EGFRExon 19 deletion

EGFRT790M


[References]

[1]. WO 2013014448 A1


[Related Small Molecules]

Osimertinib (AZD9291) | Tyrphostin B42 (AG-490) | Neratinib (HKI-272) | Genistein | (-)-Epigallocatechin gallate | AG-1478 | Dacomitinib (PF-00299804) | Irbinitinib | Poziotinib | Olmutinib | Sapitinib | AZD-3759 | Pyrotinib | Canertinib dihydrochloride | BMS-690514

Chemical & Physical Properties

[ Molecular Formula ]:
C27H30ClN7O2

[ Molecular Weight ]:
520.02600

[ Exact Mass ]:
519.21500

[ PSA ]:
98.41000

[ LogP ]:
5.29880

[ Storage condition ]:
2-8℃

Related Compounds