(S)-Donepezil

Names

[ CAS No. ]:
142057-80-5

[ Name ]:
(S)-Donepezil

[Synonym ]:
(2S)-2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone
(2S)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
donepezil
(S)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-Inden-1-one
(S)-donepezil
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, (2S)-

Biological Activity

[Description]:

(S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Lili W, et al. Steady-state plasma concentration of donepezil enantiomers and its stereoselective metabolism and transport in vitro. Chirality. 2013 Sep;25(9):498-505.  

[2]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
527.9±50.0 °C at 760 mmHg

[ Melting Point ]:
206.72° C

[ Molecular Formula ]:
C24H29NO3

[ Molecular Weight ]:
379.49

[ Flash Point ]:
273.1±30.1 °C

[ Exact Mass ]:
379.214752

[ LogP ]:
4.71

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.578