Niclosamide olamine

Names

[ Name ]:
Niclosamide olamine

[Synonym ]:
Luomiecide
Hl 2448
MFCD01941566
EINECS 215-811-7
Mollutox
2',5-dichloro-4'-nitrosalicylanilide
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide - 1-propanamine (1:1)
Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with 1-propanamine (1:1)
clonitralid
Niclosamide ethanolamine salt
2’,5-dichloro-4’-nitrosalicylanilide - 2-aminoethanol (1:1)
BAYER73
(2-hydroxyethyl)ammonium 4-chloro-2-[(2-chloro-4-nitroanilino)carbonyl]phenolate
BAY-73
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide—2-aminoethan-1-ol
Snanilcide
BAYER-6076
Clonitralide
NICLOSAMIDEL
5,2'-dichloro-4'-nitro-salicylanilide ethanolamine salt
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)

Biological Activity

[Description]:

Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Signaling Pathways >> JAK/STAT Signaling >> STAT

Signaling Pathways >> Autophagy >> Autophagy

Chemical & Physical Properties

[ Boiling Point ]:
155-156 °C

[ Melting Point ]:
91-93 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₅Cl₂N₃O₅

[ Molecular Weight ]:
386.230

[ Flash Point ]:
149 °F

[ Exact Mass ]:
385.059601

[ PSA ]:
141.40000

[ LogP ]:
4.09340

[ Stability ]:
Stable. Hydrolyzes in concentrated acidic or basic solutions.

[ Water Solubility ]:
soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN8575000

CAS REGISTRY NUMBER :: 1420-04-8

LAST UPDATED :: 199607

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H8-Cl2-N2-O4.C2-H7-N-O

MOLECULAR WEIGHT :: 388.23

WISWESSER LINE NOTATION :: WNR CG DMVR BQ EG &Z2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,103,1976/1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,126,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 336600 ug/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 53,1,1995 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
4.1