16-Hydroxycleroda-3,13-dien-15,16-olide

Names

[ CAS No. ]:
141979-19-3

[ Name ]:
16-Hydroxycleroda-3,13-dien-15,16-olide

Biological Activity

[Description]:

16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase

Research Areas >> Metabolic Disease

[References]

[1]. Po-Kai Huang, et al. Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. Int J Mol Sci. 2019 Jan 27;20(3):530.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₃₀O₃

[ Molecular Weight ]:
318.45

[ Storage condition ]:
2-8℃

Related Compounds

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