AMG-333

Names

[ CAS No. ]:
1416799-28-4

[ Name ]:
AMG-333

[Synonym ]:
MFCD31813692

Biological Activity

[Description]:

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

[Target]

IC50: 13 nM (TRPM8)[1]

[References]

[1]. Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₂F₅N₃O₄

[ Molecular Weight ]:
453.32

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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