Vat-Cit-PAB-Monomethyl Dolastatin 10

Names

[ Name ]:
Vat-Cit-PAB-Monomethyl Dolastatin 10

[Synonym ]:
L-Ornithinamide, L-valyl-N5-(aminocarbonyl)-N-[4-[(5S,8S,11S,12R)-12-[2-[(2R)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-2-oxoethyl]-4,1 0-dimethyl-5,8-bis(1-methylethyl)-11-[(1S)-1-methylpropyl]-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl]-
L-Valyl-N-{4-[(5S,8S,11S,12R)-11-[(2S)-2-butanyl]-5,8-diisopropyl-12-(2-{(2R)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]-1-pyrrolidinyl}-2-oxoethyl)- ;4,10-dimethyl-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl}-N5-carbamoyl-L-ornithinamide

Biological Activity

[Description]:

Vat-Cit-PAB-Monomethyl Dolastatin 10 is a drug-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Auristatin

[References]

[1]. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1237.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆₀H₉₃N₁₁O₁₁S

[ Molecular Weight ]:
1176.512

[ Flash Point ]:
702.0±34.3 °C

[ Exact Mass ]:
1175.677612

[ LogP ]:
6.49

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.564

Related Compounds

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